담관암종에서 혈청반응인자의 발현과 예후 인자로서의 의의
Expression and Prognostic Significance of Serum Response Factor in Cholangiocarcinoma
박신영, 박호성, 조백환, 유희철, 장규윤, 정명자, 문우성, 김요나, 김희진, 김경렬,
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박신영 ( Park Shin-Young )
전북대학교 의과대학 병리학교실
박호성 ( Park Ho-Sung )
전북대학교 의과대학 병리학교실
조백환 ( Cho Baik-Hwan )
전북대학교 의학전문대학원 외과학교실
유희철 ( Yu Hee-Chul )
전북대학교 의과대학 외과학교실
장규윤 ( Jang Kyu-Yun )
전북대학교 의과대학 병리학교실
정명자 ( Chung Myoung-Ja )
전북대학교 의과대학 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실
김요나 ( Kim Yo-Na )
전북대학교 의과대학 병리학교실
김희진 ( Kim Hee-Jin )
전북대학교 의과대학 병리학교실
김경렬 ( Kim Kyung-Ryul )
국립과학수사연구소
KMID : 0357920090430060517
Abstract
Background: Serum response factor (SRF) is a transcriptional factor that plays an important role in cell growth and differentiation for several types of cells. The expression of SRF in cholangiocarcinoma (CC) and its potential role has not been examined. The aim of this study was to determine the relationship between the expression of SRF in CC and the clinicopathological parameters, as well as patient survival.
Methods: We analyzed the expression of SRF in 84 surgically resected cases of CC (33 cases of intrahepatic CC [ICC] and 51 cases of extrahepatic CC [ECC]) by using immunohistochemistry.
Results: The positive expression of SRF was detected in 48.8% of the cases of CC (42.4% in ICC, 52.9% in ECC). SRF was predominantly expressed in the CC cells with intense labeling in the nucleus. A SRF expression was significantly associated with the cell proliferation rate (Ki-67 labeling index, p=0.046) and poor patient survival (p=0.002). The tumor differentiation (p=0.038), the T category (p<0.001), lymph node and distant metastasis (p<0.001, p=0.009) and nerve and vessel invasion (p=0.010, p=0.012) were also found to be significantly associated with a poor CC prognosis.
Conclusions: These results suggest that the SRF may play a role in the tumor cell proliferation of CC, and its expression in tumor cells can provide additional prognostic information.
키워드
Cholangiocarcinoma;Serum response factor;Liver
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