피부 편평세포암종의 악성화 과정에서 G1/S 세포주기 조절 단백의 이상 발현
Alteration of G1/S Cell Cycle Regulatory Proteins in Carcinogenesis of Cutaneous Squamous Cell Carcinomas
임소영, 이교영, 정지한, 유진영, 강석진, 최현주, 유창영,
소속 상세정보
임소영 ( Im So-Young )
가톨릭대학교 의과대학 병원병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 병원병리학교실
정지한 ( Jung Ji-Han )
가톨릭대학교 의과대학 병원병리학교실
유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 병원병리학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 병원병리학교실
최현주 ( Choi Hyun-Joo )
가톨릭대학교 의과대학 병리학교실
유창영 ( Yoo Chang-Young )
가톨릭대학교 의과대학 병원병리학교실
KMID : 0357920090430060542
Abstract
Background: Aberration of the cell cycle regulatory proteins has been reported to contribute to the development and progression of human malignancy. We studied the expression of G1/S cell cycle regulatory proteins to investigate the carcinogenesis in cutaneous squamous cell lesions.
Methods: We evaluated the expressions of p16, pRb, cyclin D1 and Ki-67 protein by immunonohistochemistry in cases of normal skin (n=15), seborrheic keratosis (SK; n=26), actinic keratosis (AK; n=30), Bowen’s disease (BD; n=37), keratoacanthoma (KA; n=23), and squamous cell carcinoma (SCC; n=22).
Results: The Ki-67 expression gradually increased from SK, through AK, to BD. The expression of p16 was more increased in BD than that in AK. The decreased expressions of p16 and Rb, and the increased expression of cyclin D1 were observed to a greater degree in SCC than those in BD. The expressions of cyclin D1 and Ki-67 were higher in SCC than those in KA.
Conclusions: The altered expressions of p16, Rb, and cyclin D1 were considered to be related to the carcinogenesis in the cutaneous squamous cell lesions. Therefore, immunohistochemical studies of the cell cycle regulatory proteins and a combined analysis may be helpful as an adjunct to the histomorphology in the diagnosis of cutaneous squamous cell lesions.
키워드
Skin;Carcinoma;Squamous cell;Cell cycle
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