The Prognostic Significance of the Tumor-Infiltrating FoxP3-Positive Regulatory T Cells in Gastric Carcinoma
노상재, 박신영, 김경렬, 김찬영, 권근상, 박호성, 이호, 정명자, 문우성, 장규윤,
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노상재 ( Noh Sang-Jae )
전북대학교 의과대학 병리학교실 및 의과학연구소
박신영 ( Park Shin-Young )
전북대학교 의과대학 병리학교실
김경렬 ( Kim Kyung-Ryoul )
국립과학수사연구소
김찬영 ( Kim Chan-Young )
전북대학교 의학전문대학원 외과학교실
권근상 ( Kwon Keun-Sang )
전북대학교 의과대학 예방의학교실 및 의과학연구소
박호성 ( Park Ho-Sung )
전북대학교 의과대학 병리학교실
이호 ( Lee Ho )
전북대학교 의학전문대학원 법의학교실
정명자 ( Chung Myoung-Ja )
전북대학교 의과대학 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실
장규윤 ( Jang Kyu-Yun )
전북대학교 의과대학 병리학교실
KMID : 0357920100440010009
Abstract
Background: Regulatory T cells (Tregs) are known to be key regulators of immune responses in patients with autoimmune disease and infection and also for attenuating antitumor immunity by the host. It has been reported that high numbers of tumor-infiltrating Tregs might be associated with poor clinical outcomes for several malignant tumors. Therefore, this study aimed to examine the impact of tumor-infiltrating Tregs on the prognosis of gastric carcinoma patients.
Methods: The immunohistochemical staining for anti-fork head Box P3 (FoxP3) antibody was performed by using a 3 mm core from the tumor specimens of each of the 173 gastric cancer patients for constructing a tissue microarray. FoxP3-positive Tregs were quantified by calculating the numbers of positive cells per 5 high-power fields on light microscopy. Thereafter, the 173 patients were subdivided into the low Tregs group (≤ 3/5 high power fields [HPF], n = 41) and the high Tregs group (> 3/5 HPF, n = 132).
Results: The high Tregs group was significantly associated with a higher stage, more invasion depth and lymph node metastasis (p = 0.009, p = 0.036, p = 0.006, respectively). The high Tregs group showed significantly poorer overall survival and event-free survival (p = 0.004, p = 0.017, respectively) on the univariate analysis. The Tregs group and the tumor, node and metastasis stage were also independent prognostic factors that were significantly associated with overall survival (p = 0.025, p < 0.001, respectively) by multivariate analysis.
Conclusions: Our results indicated that a high number of tumor-infiltrating FoxP3-positive Tregs could be an indicator of poor long term survival for gastric carcinoma patients.
키워드
T-lymphocytes;regulatory;FoxP3 protein;human;Stomach neoplasms
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