The Prognostic Subgroups as Defined by the Patterns of Epstein-Barr Virus Infection in Patients with Hodgkin Lymphoma
노지현, 김석진, 김원석, 고영혜,
소속 상세정보
노지현 ( Roh Ji-Hyeon )
성균관대학교 의과대학 삼성서울병원 병리학교실
김석진 ( Kim Seok-Jin )
성균관대학교 의과대학 삼성서울병원 혈액종양내과
김원석 ( Kim Won-Seog )
성균관대학교 의과대학 삼성서울병원 혈액종양내과
고영혜 ( Ko Young-Hyeh )
성균관대학교 의과대학 삼성서울병원 병리과
KMID : 0357920100440010022
Abstract
Background: The purpose of this study was to investigate the prognostic significance of the Epstein-Barr virus (EBV) infected non-neoplastic lymphocytes in patients with Hodgkin lymphoma (HL).
Methods: Seventy-seven cases of HL were evaluated by immunohistochemical analysis and EBV-encoded RNA in situ hybridization. The cases were divided into three groups according to the EBV status. EBV was negative in 48 cases (group 1), EBV was located in the Hodgkin/Reed-Sternberg (HRS) cells, but not in the non-neoplastic lymphocytes in 20 cases (26%) (group 2) and EBV was located in both the HRS cells and the non-neoplastic lymphocytes in 9 cases (12%) (group 3).
Results: The groups differed with respect to the age distribution, the clinical presentation and the prognosis. The median ages were 30 (group 1), 47.5 (group 2) and 23 years (group 3) (p = 0.011). B symptoms (p = 0.007) and the histologic subtype of mixed cellularity classical HL (p = 0.001) were more common in the EBV-positive patients than in their EBV-negative counterparts. Two patients from group 3 had associated chronic EBV infection syndrome. The five-year survival rate was 97.56% in group 1, 75.76% in group 2 and 100% in group 3 (p = 0.0178).
Conclusions: HL with EBV located in both the HRS cells and the non-neoplastic lymphocytes is a distinct prognostic subgroup that has better survival than the HL with EBV located in only the HRS cells.
키워드
Herpesvirus 4;human;Hodgkin disease;In situ hybridization
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