Pathologic Findings of Surgically Resected Nontuberculous Mycobacterial Pulmonary Infection
송혜종, 안정석, 한정호, 고원정, 김홍광, 최용수,
소속 상세정보
송혜종 ( Song Hye-Jong )
성균관대학교 의과대학 삼성서울병원 병리과
안정석 ( An Jung-Suk )
성균관대학교 의과대학 삼성서울병원 병리학교실
한정호 ( Han Joung-Ho )
성균관대학교 의과대학 삼성서울병원 병리학교실
고원정 ( Koh Won-Jung )
성균관대학교 의과대학 삼성서울병원 내과학교실
김홍광 ( Kim Hong-Kwang )
성균관대학교 의과대학 삼성서울병원 흉부외과
최용수 ( Choi Yong-Soo )
성균관대학교 의과대학 삼성서울병원 흉부외과학교실
KMID : 0357920100440010056
Abstract
Background: Surgical resection of the involved lung for nontuberculous mycobacteria (NTM) has become an important curative therapy. However, there is limited information on the histopathological features of NTM pulmonary disease in Korean patients with NTM infection.
Methods: We evaluated 51 specimens from 49 patients who were treated at our referral center from 2002 to 2009.
Results: Almost all the cases showed bronchiectasis with lymphocytic infiltration. Variable features of granulomatous inflammation were found; well-defined granulomas in the parenchyma (68.6%), pneumonia-like granulomatous lesions (49.0%) and granulomatous inflammation in the bronchial wall (41.2%) were identified. The microscopic findings of cavitary lesions (37.3%) showed that these lesions were composed of granulomas and necrosis.
Conclusions: The differentiation of tuberculosis from NTM could not be accurately made based solely on the histological features. However, the airway centered tendency of NTM reflected an airborn etiology, and this could be correlated with the classification according to the radiological findings. In addition, coexisting constitutional lung diseases, and especially bronchiectasis, were suspected to be predisposing conditions for NTM organisms to colonize and progress to true NTM pulmonary disease.
키워드
Mycobacterium;atypical;Tuberculosis;Lung
원문 및 링크아웃 정보
등재저널 정보