정상 만삭 태반 및 전자간증 태반에서 중간 영양막 세포의 조직학적 및 면역조직학적 소견
Histological and Immunohistochemical Findings of the Intermediate Trophoblasts in Normal Full Term and Pre-eclamptic Placentas
한상학, 김규래, 이용희, 노재윤,
소속 상세정보
한상학 ( Han Sang-Hak )
울산대학교 의과대학 병리학교실
김규래 ( Kim Kyu-Rae )
울산대학교 의과대학 서울아산병원 병리과
이용희 ( Lee Yong-Hee )
울산대학교 의과대학 병리학교실
노재윤 ( Ro Jae Y. )
울산대학교 의과대학 서울아산병원 병리과
KMID : 0357920100440010063
Abstract
Background: Recent studies have suggested that implantation site intermediate trophoblasts (ISITs) and chorionic type intermediate trophoblasts (CTITs) show different immunohistochemical findings, and that each type has specific location in placentas. However, we observed that both subtypes are intimately admixed in many areas of the placentas and both types are proliferated around the infarcts.
Methods: In order to examine the site specificity in their distribution and the changes of intermediate trophoblasts (ITs), if any, in the pre-eclamptic placentas, quantitative analyses of ISITs and CTITs using p63, CD146, placental alkaline phosphatase, human placental lactogen, and α-inhibin were performed in normal and pre-eclamptic placentas containing infarcts.
Results: In the fetal membranes of both normal and pre-eclamptic placentas, CTITs and ISITs were equally identified, forming distinct layers. ISITs were predominant in the intervillous septum and basal plate, while CTITs were predominant in the subchorionic area. At the margin of infarcts in pre-eclamptic placentas, both subtypes were increased in number, forming distinct layers.
Conclusions: The subtypes of ITs do not have site specificity in placentas. Increased number of ITs and zonal distribution around infarcts suggest that CTITs and ISITs have differentiation associated relationship, and the differentiation might be related to the microenvironment of placenta, such as intraplacental oxygen concentration.
키워드
Placenta;Trophoblasts;Pre-eclampsia;Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보