자궁 경부 Human Papillomavirus DNA Chip 검사의 분석
The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix
정주현, 조현이, 김나래, 정동해, 박상희, 하승연,
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정주현 ( Jeong Joo-Hyeon )
가천의과학대학교 의학전문대학원 병리학교실
조현이 ( Cho Hyun-Yee )
가천의과학대학교 길병원 병리과학교실
김나래 ( Kim Na-Rae )
가천의대 길병원 병리과
정동해 ( Chung Dong-Hae )
가천의과학대학교 길병원 병리학교실
박상희 ( Park Sang-Hui )
가천의과학대학교 길병원 병리학교실
하승연 ( Ha Seung-Yeon )
가천의과학대학교 길병원 병리과학교실
KMID : 0357920100440010077
Abstract
Background: The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution.
Methods:In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546).
Results: Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV. Single infection occurred most commonly (72.1% of women). HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11. The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05).
Conclusions: HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years.
키워드
Human papillomavirus;Oligonucleotide array sequence analysis;Cytology;Cervix uteri
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