자연 경과에 따른 만성 B형 간염의 간조직 내 FoxP3 양성 조절 T세포의 침윤 양상: 간 침생검 조직을 이용한 면역 조직 화학적 연구
Frequency of Intrahepatic FoxP3+ Regulatory T cells during the Natural Course of Chronic Hepatitis B: An Immunohistochemical Study Using Needle-Biopsied Liver Tissue
배지윤, 김현경, 강한나, 정하린, 송동은, 성순희, 구혜수, 한운섭, 이정경, 김태헌, 정규원, 조민선,
소속 상세정보
배지윤 ( Bae Ji-Yoon )
이화여자대학교 의학전문대학원 병리학교실
김현경 ( Kim Hyung-Kyung )
이화여자대학교 의학전문대학원 병리학교실
강한나 ( Kang Han-Na )
이화여자대학교 의학전문대학원 병리학교실
정하린 ( Cheong Ha-Rin )
이화여자대학교 의학전문대학원 병리학교실
송동은 ( Song Dong-Eun )
이화여자대학교 의학전문대학원 병리학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의학전문대학원 병리학교실
구혜수 ( Koo Hae-Soo )
이화여자대학교 의학전문대학원 병리학교실
한운섭 ( Han Woon-Sup )
이화여자대학교 의학전문대학원 병리학교실
이정경 ( Lee Jeong-Kyong )
이화여자대학교 의학전문대학원 영상의학과학교실
김태헌 ( Kim Tae-Hun )
이화여자대학교 의학전문대학원 내과학교실
정규원 ( Chung Kyu-Won )
가톨릭대학교 의과대학 인천성모병원 내과학교실
조민선 ( Cho Min-Sun )
이화여자대학교 의학전문대학원 병리학교실
KMID : 0357920100440020132
Abstract
Background: Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized.
Methods: Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+ T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry.
Results: The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load.
Conclusions: FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV.
키워드
Hepatitis B;chronic;T-lymphocytes;regulatory;FoxP3
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