Prognostic Value of Phosphorylated Akt and Survivin Expression in Gastric Adenocarcinoma
이숭, 김윤철, 이현민, 이기상, 신병철, 김형석, 이제혁, 박창수, 이경화,
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이숭 ( Lee Soong )
서남대학교 의과대학교 내과학교실
김윤철 ( Kim Yun-Cheol )
서남대학교 의과대학 내과학교실
이현민 ( Lee Hyun-Min )
서남대학교 의과대학 내과학교실
이기상 ( Lee Ki-Sang )
서남대학교 의과대학 내과학교실
신병철 ( Shin Byung-Chul )
서남대학교 의과대학 내과학교실
김형석 ( Kim Hyung-Seok )
전남대학교 의과대학 법의학교실
이제혁 ( Lee Jae-Hyuk )
전남대학교 의과대학 병리학교실
박창수 ( Park Chang-Soo )
전남대학교 의과대학 병리학교실
이경화 ( Lee Kyung-Hwa )
전남대학교 의과대학 병리학교실
KMID : 0357920100440030252
Abstract
Background: pAkt (the phosphorylated form of the proto-oncogene protein c-akt) and survivin (human BIRC5 protein) are candidate apoptosis-related molecules that may be responsible for cancer progression. The aim of this study was to determine the expression of pAkt and survivin in malignant stomach neoplasm, and their value as prognostic indicators of cancer.
Methods: The expression of pAkt and survivin in 144 cases of gastric cancer was detected by immunohistochemistry and compared with established clinicopathological parameters and prognosis of this disease.
Results: Expression of pAkt showed significant correlations with depth of invasion, lymph node and distant metastasis, as well as the stage (p < 0.05 for all three correlations), but not with the Lauren classification. Survivin expression closely correlated with histological type, Lauren classification, depth of invasion, metastasis, and stage (p < 0.05 for all). The overall survival of patients with pAkt/survivin expression was inferior to that of patients with loss of pAkt/survivin expression. Cox multivariate analysis demonstrated a significant correlation between stage (p = 0.04), survivin expression (p = 0.02), and prognosis.
Conclusions: Patients with pAkt/survivin expression in gastric cancer are at increased risk of cancer-related mortality via the apoptosis resistance pathway. Expression of pAkt and survivin could be used as a prognostic indicator for gastric cancer.
키워드
Proto-oncogene proteins c-akt;BIRC5 protein;human;Stomach neoplasms;Apoptosis
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