Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma
김연숙, 이상신, 송지용, 김은철, 이석근,
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김연숙 ( Kim Yeon-Sook )
청주대학교 치과대학 치위생학과
이상신 ( Lee Sang-Shin )
강릉원주대학교 치과대학 구강병리학교실
송지용 ( Song Ji-Yong )
강릉원주대학교 치과대학 구강병리학교실
김은철 ( Kim Eun-Cheol )
원광대학교 치과대학 구강악안면병리학교실
이석근 ( Lee Suk-Keun )
강릉원주대학교 치과대학 구강병리학교실
KMID : 0357920100440030284
Abstract
Background: The protein expression profile of clear cell type mucoepidermoid carcinoma (MEC) is not well known.
Methods: We examined a case of clear cell type MEC by immunohistochemical (IHC) array using 59 antibodies against oncoproteins, proliferation-related proteins, apoptosis-related proteins, growth factor-related proteins, angiogenesis-related proteins, and matrix proteins.
Results: MEC tumor cells showed 40 to 60% more expression of BCL-2 and cyclin-dependent kinase 4 than normal gingival tissue, and 20-40% more expression of BCL-2-associated agonist of cell death, deleted in malignant brain tumors 1, E-cadherin, eIF5A, hypoxia-inducible factor, vimentin, and Wnt-1. Expression of other proteins, including p53, epidermal growth factor receptor, proliferating cell nuclear antigen, survivin, carcinoembryonic antigen, β-catenin, poly-ADP ribose-polymerase, etc. were relatively weak in MEC tumor cells.
Conclusions: The IHC array for our MEC contained strong oncogenic signals involving Wnt-1/adenomatous polyposis coli, tumor necrosis factor a/signal transducer and activator of transcription 3/BCL-2, and pAKT pathways, signals that could result in the prolonged survival of clear tumor cells.
키워드
Oncogenes;Immunohistochemistry;Array
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