초미세 갑상샘 유두암종에서의 BRAF 돌연변이 검출
The Frequency of BRAF Mutation in Very Small Papillary Thyroid Carcinomas
김태은, 노지현, 박희정, 권지은, 강소영, 최윤라, 오영륜,
소속 상세정보
김태은 ( Kim Tae-Eun )
성균관대학교 의과대학 삼성서울병원 병리학교실
노지현 ( Roh Ji-Hyeon )
성균관대학교 의과대학 삼성서울병원 병리학교실
박희정 ( Park Hee-Jung )
성균관대학교 의과대학 삼성서울병원 병리학교실
권지은 ( Kwon Jee-Eun )
성균관대학교 의과대학 삼성서울병원 병리학교실
강소영 ( Kang So-Young )
성균관대학교 의과대학 삼성서울병원 병리학교실
최윤라 ( Choi Yoon-La )
성균관대학교 의과대학 삼성서울병원 병리학교실
오영륜 ( Oh Young-Lyun )
성균관대학교 의과대학 삼성서울병원 병리학교실
KMID : 0357920100440030308
Abstract
Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid and BRAF (V600E) is the most frequent genetic alteration in PTCs. The aim of this study was to investigate the frequency of BRAF mutation, especially in very small PTCs.
Methods: We analyzed the presence of the BRAF mutation in PTCs in subgroups defined by tumor size (0.5 cm intervals).
Results: Of 140 patients, 85 (60.7%) showed a BRAF mutation. The frequency of BRAF mutation in the subgroup was: 45/70 (64.3%) in tumors less than 0.5 cm in size, 18/28 (64.3%) in 0.6-1 cm tumors, 10/22 (45.5%) in 1.1-1.5 cm tumors, and 12/20 (60.0%) in 1.6-2 cm tumors. There was no statistically significant association between BRAF mutation and tumor size (p = 0.44). Similarly, BRAF mutation was not statistically related to age, sex, stage, perithyroidal extension or lymph node metastasis. On multivariate logistic regression analysis, tumor sizes larger than 0.5 cm were associated with lymph node metastasis (odds ratio, 3.79; 95% confidence interval, 1.81 to 7.91; p < 0.01).
Conclusions: The BRAF mutation is not related to tumor size even in very small PTCs. The similar frequency of BRAF mutation in very small PTCs suggests that the BRAF mutation is a very early event in the tumorigenesis of PTCs.
키워드
Thyroid gland;BRAF;Carcinoma;papillary
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