Mycophenolate Mofetil-Related Colitis - A Case Report -
김경은, Gardner Jerad M., Schwartz Mary, Tompson Matthew L., 노재윤,
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김경은 ( Kim Kyung-Eun )
울산대학교 의과대학 서울아산병원 병리학교실
( Gardner Jerad M. )
USA Weill Medical College of Cornell University The Methodist Hospital Departments of Pathology
( Schwartz Mary )
USA Weill Medical College of Cornell University The Methodist Hospital Departments of Pathology
( Tompson Matthew L. )
USA Weill Medical College of Cornell University The Methodist Hospital Departments of Internal Medicine
노재윤 ( Ro Jae Y. )
울산대학교 의과대학 서울아산병원 병리과
KMID : 0357920100440030333
Abstract
Mycophenolate mofetil (MMF)-related colitis is one of the common causes of afebrile diarrhea in transplant patients. Pathologic diagnosis of MMF-related colitis is difficult because microscopic findings of MMF effects resemble those of graft-versus-host disease, inflammatory bowel disease and ischemic colitis. However, if diagnosed, MMF-induced colitis can be markedly improved by discontinuing the drug. A 70-year-old man having a history of transplantation presented with a one month history of afebrile diarrhea. Colonoscopy revealed patchy erosions. The colonoscopic biopsy specimen showed not only crypt disarray with degenerated crypts and scattered epithelial cell apoptosis, but also stromal inflammatory cell infiltration. A review of his medical records showed that he had been taking immunosuppressive drugs including MMF since his heart transplantation 6 years prior. The histologic findings of colonic mucosa were consistent with MMF-related colitis. After discontinuing MMF, the diarrhea quickly resolved and has not recurred for 10 months.
키워드
Mycophenolate mofetil;Transplants;Diarrhea;Colitis
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