Prognostic Significance of Glycolytic Metabolic Change Related to HIF-1α in Oral Squamous Cell Carcinomas
홍숙희, 노상영, 고윤호, 원혜성, 이명아, 우인숙, 변재호, 강진형, 홍영선, 정찬권, 김연실, 주영훈, 김민식,
소속 상세정보
홍숙희 ( Hong Sook-Hyee )
가톨릭대학교 의과대학 내과학교실
노상영 ( Roh Sang-Young )
가톨릭대학교 의과대학 내과학교실
고윤호 ( Ko Yoon-Ho )
가톨릭대학교 의과대학 내과학교실
원혜성 ( Won Hye-Sung )
가톨릭대학교 의과대학 내과학교실
이명아 ( Lee Myung-Ah )
가톨릭대학교 의과대학 내과학교실
우인숙 ( Woo In-Sook )
가톨릭대학교 의과대학 내과학교실
변재호 ( Byeon Jae-Ho )
가톨릭대학교 의과대학 내과학교실
강진형 ( Kang Jin-Hyoung )
가톨릭대학교 의과대학 내과학교실
홍영선 ( Hong Young-Seon )
가톨릭대학교 의과대학 내과학교실
정찬권 ( Jung Chan-Kwon )
가톨릭대학교 의과대학 병리학교실
김연실 ( Kim Yeon-Sil )
가톨릭대학교 강남성모병원 방사선종양학과
주영훈 ( Joo Young-Hoon )
가톨릭대학교 의과대학 이비인후과학교실
김민식 ( Kim Min-Sik )
가톨릭대학교 의과대학 이비인후과학교실
KMID : 0357920100440040360
Abstract
Background: Growing tumors adapt to a hypoxic environment and increase anaerobic glycolysis. This metabolic switch is related to aggressive behavior. We investigated the relationship between glycolytic metabolism biomarkers associated with hypoxia-inducible factor (HIF)-1α and prognosis.
Methods: We performed immunohistochemical staining of HIF-1α, pyruvate dehydrogenase kinase (PDK) 1 and lactate dehydrogenase (LDH) 5 in 74 patients with oral squamous cell carcinoma (SCC) who had received curative radical resection.
Results: High reactivity of HIF-1α, PDK 1 and LDH 5 was observed in 29 (39.2%), 32 (43.2%) and 54 (73.0%) patients, respectively. Expression levels of the three biomarkers were significantly correlated. All three markers were highly expressed in 16 (21.6%) patients. Elevated expression of the three markers was associated with increased invasiveness (p = 0.043) and recurrence (p = 0.017) of tumors. In survival analysis, upregulation of the three markers was additionally associated with shorter disease free survival (DFS, p = 0.001) and overall survival (OS, p = 0.002). High expression of all three markers was a strong independent prognostic factor for DFS (p = 0.030) and OS (p = 0.026).
Conclusions: Oral SCC with altered glycolytic metabolism exhibits a more invasive and aggressive phenotype. Our results indicate that glycolytic metabolism biomarkers related to HIF-1α may be independent prognostic factors in patients with oral SCC.
키워드
Carcinoma; squamous cell; HIF1A protein; human; Lactate dehydrogenase 5; Pyruvate dehydrogenase (acetyl-transferring) kinase
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