Clinicopathological Significance of Invasive Ductal Carcinoma with High Prevalence of CD44+/CD24-/low Tumor Cells in Breast Cancer
성지연, 김교영, 박용구, 이주희, 김윤화, 임성직,
소속 상세정보
성지연 ( Sung Ji-Youn )
경희대학교 의과대학 병리학교실
김교영 ( Kim Gou-Young )
경희대학교 동서신의학병원 병리학과학교실
박용구 ( Park Yong-Koo )
경희대학교 의과대학 병리학교실
이주희 ( Lee Ju-Hie )
경희대학교 의과대학 병리학교실
김윤화 ( Kim Youn-Hwa )
경희대학교 의과대학 병리학교실
임성직 ( Lim Sung-Jig )
경희대학교 동서신의학병원 병리학과학교실
KMID : 0357920100440040390
Abstract
Background: Epithelial tumor cells with a CD44+/CD24-/low immunoprofile may have the ability to cause breast cancer. We studied these cells and their clinicopathological significance.
Methods: The clinicopathologic findings of 100 invasive ductal carcinoma (IDC) cases and 45 ductal carcinoma in situ (DCIS) cases were reviewed. CD44+/CD24-/low tumor cells were identified by immunohistochemistry, and their clinicopathological implications in IDC and DCIS were analyzed.
Results: IDC with a high prevalence of CD44+/CD24-/low tumor cells was significantly associated with larger mass, higher grade, estrogen receptor (ER) negativity, and tumor cells with a higher frequency of metastasis. The proportion of CD44+/CD24-/low tumor cells in IDC, and its DCIS components was not significantly different, whereas the proportion of CD44+/CD24-/low tumor cells was higher in DCIS than in the DCIS component of IDC (p < 0.001).
Conclusions: IDC with a high prevalence of CD44+/CD24-/low tumor cells might correlate with aggressive features, such as ER and higher grades. Moreover, the proportion of CD44+/CD24-/low tumor cells in the DCIS components of IDC and DCIS might harbor different biology, which may lead to differences in cancer progression and early carcinogenesis.
키워드
Neoplastic stem cells; CD44 protein; human; CD24 protein; human; Invasive ductal carcinoma; Carcinoma; intraductal; noninfiltrating
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