Expression of MUC1 and MUC4 and Its Prognostic Significance in Non-Small Cell Lung Carcinoma
전지민, 이혜원, 박지영, 정혜라, 황일선, 권선영, 최미선, 강유나, 김상표, 이상숙, 최원일, 권건영,
소속 상세정보
전지민 ( Jeon Ji-Min )
계명대학교 의과대학 병리학교실
이혜원 ( Lee Hye-Won )
계명대학교 의과대학 병리학교실
박지영 ( Park Ji-Young )
계명대학교 의과대학 병리학교실
정혜라 ( Jung Hae-Ra )
계명대학교 의과대학 병리학교실
황일선 ( Hwang Il-Seon )
계명대학교 의과대학 병리학교실
권선영 ( Kwon Sun-Young )
계명대학교 의과대학 병리학교실
최미선 ( Choe Mi-Sun )
계명대학교 의과대학 병리학교실
강유나 ( Kang Yu-Na )
계명대학교 의과대학 병리학교실
김상표 ( Kim Sang-Pyo )
계명대학교 의과대학 병리학교실
이상숙 ( Lee Sang-Sook )
계명대학교 의과대학 병리학교실
최원일 ( Choi Won-Il )
계명대학교 의과대학 내과학교실
권건영 ( Kwon Kun-Young )
계명대학교 의과대학 병리학교실
KMID : 0357920100440040397
Abstract
Background: Mucin (MUC)1 and MUC4 (MUC1, 4) are high molecular weight glycoproteins expressed in normal and malignant epithelial cells, and these expressions are related to the prognosis of some carcinomas. In non-small cell lung carcinoma (NSCLC), the relationship between MUC1, 4 expressions and their prognostic significance is not well known. We evaluated these relationships in a series of NSCLC: 1) between MUC1, 4 expression levels and histologic subtypes, and 2) between high expression of MUC1, 4 and their prognostic significance.
Methods: We performed immunohistochemical staining for MUC1, 4 in paraffin-embedded tissues from 165 NSCLC cases arranged in a tissue microarray.
Results: We found a significant correlation between MUC1, 4 expressions and NSCLC histologic subtypes (p < 0.05). High MUC1 expression was characteristic of adenocarcinoma. Low MUC1, 4 expressions were characteristic of squamous cell carcinoma. In adenocarcinoma, we found significant association between diffuse MUC1 expression and short patient survival (p = 0.005). In squamous cell carcinoma, diffuse MUC4 expression showed long patient survival trend (p = 0.128).
Conclusions: MUC1, 4 expression levels were significantly correlated with NSCLC histologic subtypes. Diffuse MUC1 expression was significantly associated with shortened survival in NSCLC patients, especially in adenocarcinoma.
키워드
Mucin-1; MUC4 protein; human; Carcinoma; non-small cell; Prognosis
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