Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast
김가언, 김영, 정은희, 김조헌, 박민호, 이지신,
소속 상세정보
김가언 ( Kim Ga-Eon )
전남대학교 의과대학 병리학교실
김영 ( Kim Young )
전남대학교 의과대학 병리학교실
정은희 ( Jeong Eun-Hui )
전남대학교 의과대학 병리학교실
김조헌 ( Kim Jo-Heon )
전남대학교 의과대학 병리학교실
박민호 ( Park Min-Ho )
전남대학교 의과대학 외과학교실
이지신 ( Lee Ji-Shin )
전남대학교 의과대학 병리학교실
KMID : 0357920100440040431
Abstract
Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-β, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-α, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.
키워드
Breast; Fibroadenoma; Muscle cells; Metaplasia
원문 및 링크아웃 정보
등재저널 정보