HPV Genotyping in Squamous Cell Carcinoma of Upper Aerodigestive Tract
김영, 정은희, 민병우, 김성순, 최유덕, Jung Woon-Jae, 남종희, 박창수,
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김영 ( Kim Young )
전남대학교 의과대학 병리학교실
정은희 ( Jeong Eun-Hui )
전남대학교 의과대학 병리학교실
민병우 ( Min Byung-Woo )
전남대학교 의과대학 병리학교실
김성순 ( Kim Sung-Sun )
전남대학교 의과대학 병리학교실
최유덕 ( Choi Yoo-Duk )
전남대학교 의과대학 병리학교실
( Jung Woon-Jae )
전남대학교 의과대학 병리학교실
남종희 ( Nam Jong-Hee )
전남대학교 의과대학 병리학교실
박창수 ( Park Chang-Soo )
전남대학교 의과대학 병리학교실
KMID : 0357920100440050483
Abstract
Background : Smoking and alcohol consumption are the main risk factors for squamous cell carcinoma of the upper aerodigestive tract (SCCUAT). However, human papillomavirus (HPV) has been etiologically linked with tonsillar squamous cell carcinoma (TSCC). Therefore, we investigated the etiologic role of HPV in the context of SCCUAT in Korea.
Methods : Archival paraffin block samples from 136 cases previously diagnosed as SCCUAT were randomly selected. A commercial HPV DNA chip was used for HPV genotyping.
Results : One hundred and seventeen cases were available after checking b-globin (47 cases of tonsil and 70 of non-tonsil). A HPV-positive result (HPV 16 and 18) occurred in 13 cases of SCCUAT, and 12 cases were tonsil (25.5%, 12/47). Among the 12 HPV-positive patients with TSCC, nine were non-smokers and non-drinkers. Most HPV-negative patients with TSCC had a history of alcohol drinking and smoking (32/35, 91.4%). HPV infection status was not significantly associated with histological grade, clinical stage, or survival in patients with TSCC.
Conclusions : HPV infection was significantly higher in patients with TSCC among those with SCCUAT. HPV may be independent risk factor in development of TSCC, such as smoking and alcohol drinking.
키워드
Carcinoma; HPV; Tonsil
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