원발성 비장 혈관성 병변: 40증례의 임상병리학적, 면역조직화학적 소견과 영상의학 소견과의 비교 분석
Primary Splenic Vascular Lesions: A Clinicopathologic, Immunophenotypic and Radiopathologic Correlation Study of 40 Cases
고영화, 이희진, 최가원, 권귀영, 김은주, 허주영,
소속 상세정보
고영화 ( Koh Young-Wha )
울산대학교 의과대학 서울아산병원 병리학교실
이희진 ( Lee Hee-Jin )
울산대학교 의과대학 서울아산병원 병리학교실
최가원 ( Choi Ga-Won )
미즈메디병원 병리과
권귀영 ( Kwon Gui-Young )
중앙대학교 의과대학 부속중앙대학교병원 병리과
김은주 ( Kim Eun-Ju )
울산대학교 의과대학 서울아산병원 병리학교실
허주영 ( Huh Joo-Young )
울산대학교 의과대학 서울아산병원 병리학교실
KMID : 0357920100440050502
Abstract
Background : Primary splenic vascular lesions include the tumor and the inflammatory condition. A primary splenic vascular tumor is rare but is the most common tumor of the benign primary splenic tumors.
Methods : We describe the clinicopathological, radiological, and immunophenotypical findings of 40 cases of primary vascular lesions identified at our hospital from 1996 to 2009.
Results : The patients included 18 men and 22 women, aged 12 to 74 years, with a mean of 43.3-years and median of 40-years. They comprised 14 hemangiomas (35%), 13 lymphangiomas (32.5%), three hamartomas (7.5%), three littoral cell angiomas (7.5%), three sclerosing angiomatoid nodular transformations (SANT, 7.5%) and four angiosarcomas (10%). The majority of the patients (65%) were asymptomatic. Some of the patients (32.5%) complained of abdominal pain, and 2.5% of the patients presented with fever. Metastases were identified in 75% of the patients with an angiosarcoma at the initial work-up. One angiosarcoma patient died of the disease despite adjuvant chemoradiotherapy. The radiological findings for hamartoma, littoral cell angioma, and SANT were nonspecific. Microscopically, six types of vascular lesions showed classic morphological and immunophenotypical features of their type.
Conclusions : One should be aware of rare splenic vascular lesions when radiological findings are nonspecific. Histomorphological and immunophenotypical features are helpful for the differential diagnosis.
키워드
Spleen; Vascular lesion
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