The Fine Needle Aspiration Cytology of a Metastatic Pulmonary Adrenocortical Carcinoma Mimicking Primary Large Cell Carcinoma of the Lung
김나래, 정동해, 이재익, 하승연,
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김나래 ( Kim Na-Rai )
가천의과학대학교 길병원 병리학교실
정동해 ( Chung Dong-Hae )
가천의과학대학교 길병원 병리학교실
이재익 ( Lee Jae-Ik )
가천의과학대학교 길병원 흉부외과
하승연 ( Ha Seung-Yeon )
가천의과학대학교 길병원 병리학교실
KMID : 0357920100440050558
Abstract
Adrenocortical carcinoma is a rare neoplasm and it has an invariably lethal prognosis. We report here on the fine needle aspiration cytologic findings of a solitary metastatic pulmonary adrenocortical carcinoma in a 24-year-old woman. The aspirate smears were very cellular and they were composed of a monomorphic population of large polyhedral cells with abundant granular or vacuolated cytoplasm, and the cells were predominantly singly scattered in a necrotic background. Multinucleated pleomorphic tumor cells were also found. Pleomorphic nuclei with thickened nuclear membranes were impinging on the cell membranes. Mitotic activity was occasionally seen. The cytologic findings of pleomorphic cells with microvacuolated cytoplasm and the presence of vague gland-like sheets, as well as the patient’s history of undergoing adrenalectomy for primary adrenocortical carcinoma helped the pathologist reach the diagnosis of metastatic adrenocortical carcinoma. Here, we focus on the cytologic differential points of metastastic pulmonary adrenocortical carcinoma and primary pulmonary carcinoma, especially large cell carcinoma.
키워드
Aspiration cytology; Adrenocortical carcinoma; Neoplasm metastasis; Carcinoma; large cell; Lung neoplasms
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