Uncoupling Protein 2 (UCP2) and p53 Expression in Invasive Ductal Carcinoma of Breast
원규연, 김교영, 김윤화, 임성직, 송정윤,
소속 상세정보
원규연 ( Won Kyu-Yeoun )
경희대학교 의과대학 병리학교실
김교영 ( Kim Gou-Young )
경희대학교 동서신의학병원 병리학과학교실
김윤화 ( Kim Youn-Hwa )
경희대학교 의과대학 병리학교실
임성직 ( Lim Sung-Jig )
경희대학교 동서신의학병원 병리학과학교실
송정윤 ( Song Jeong-Yoon )
경희대학교 의과대학 외과학교실
KMID : 0357920100440060565
Abstract
Background : Uncoupling protein 2 (UCP2) is a recently identified mitochondrial inner membrane anion carrier and a negative regulator of reactive oxygen species production. In this study, we evaluated the characteristics and relationships of UCP2 and p53 expression in breast cancer tissues.
Methods : Tissue microarray slides from 107 cases of invasive ductal carcinoma of the breast were constructed, UCP2 and p53 immunohistochemical staining was conducted, and clinicopathological correlations were investigated.
Results : UCP2 expression in invasive ductal carcinoma was high in 53 cases (49.5%), while p53 expression in invasive ductal carcinoma was high in 37 cases (34.6%). UCP2 expression was correlated significantly with histological grade (p = 0.038) and mitotic count (p = 0.050). UCP2 expression was correlated significantly with p53 expression in invasive ductal carcinoma of the breast (p = 0.045). UCP2 expression (p = 0.8308) and p53 expression (p = 0.3292) showed no significant difference for the overall survival rate in patients with invasive ductal carcinoma.
Conclusions : UCP2 expression in invasive ductal carcinoma increased proportionally with histological grade and mitotic count. High UCP2 expression in invasive ductal carcinoma was observed in conjunction with high p53 expression.
키워드
Carcinoma; ductal; breast; Mitochondrial uncoupling protein 2; Tumor suppressor protein p53; Reactive oxygen species
원문 및 링크아웃 정보
등재저널 정보