간 전이를 동반한 대장암에서의 VEGF-A, VEGFR-1, VEGFR-2 발현 양상과 미세혈관 밀도의 비교
Differences in Expression of VEGF-A, VEGFR-1, VEGFR-2 and Microvessel Density in Colorectal Cancer with Liver Metastasis
정은희, 김영, 민병우, 이경화, 김현수, 이제혁,
소속 상세정보
정은희 ( Jeong Eun-Hui )
전남대학교 의과대학 병리학교실
김영 ( Kim Young )
전남대학교 의과대학 병리학교실
민병우 ( Min Byeong-Woo )
전남대학교 의과대학 병리학교실
이경화 ( Lee Kyung-Hwa )
전남대학교 의과대학 병리학교실
김현수 ( Kim Hyun-Soo )
전남대학교 의과대학 내과학교실 소화기분과
이제혁 ( Lee Jae-Hyuk )
전남대학교 의과대학 병리학교실
KMID : 0357920100440060571
Abstract
Background : Colorectal cancer (CRC) is one of the most common malignant neoplasms and is a leading cause of mortality worldwide. Metastasis to the liver is a frequent event in patients with CRC. An essential step in the metastatic cascade is angiogenesis.
Methods : This study included 45 patients who underwent a partial colectomy with hepatic resection for CRC with hepatic metastases. Immunohistochemistry was performed using vascular endothelial growth factor (VEGF)-A, VEGF receptor (VEGFR)-1, VEGFR-2, and CD34 antibodies to examine the relationship between CRC with liver metastases and angiogenesis.
Results : CRC showed significantly stronger expression of VEGF-A, VEGFR-1, and VEGFR-2 than liver metastases (p < 0.05). Microvessel density was also higher in CRC than in liver metastases (p < 0.05).
Conclusions : Compared with previous studies, we found a higher expression of VEGF-A, VEGFR-1, VEGFR-2, and microvessel density in CRC than in liver metastases, which could be ascribed to a difference in vessel distribution and blood supply in each organ. Given its profuse blood supply and distinct cell populations, the liver might provide a rich milieu for tumor cell growth with less expression of angiogenesis-inducing agents.
키워드
Thymus gland; Neoplasms; Immunohistochemistry; World Health Organization; Histological classification
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