Distribution of Dendritic Cells and Regulatory T-Cells in Cutaneous Lymphomas
유창영, 홍영선, 조백기, 김상호, 심상인, 강창석,
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유창영 ( Yoo Chang-Young )
가톨릭대학교 의과대학 성빈센트병원 병리과
홍영선 ( Hong Young-Seon )
가톨릭대학교 의과대학 내과학교실
조백기 ( Cho Baik-Kee )
가톨릭대학교 의과대학 피부과학교실
김상호 ( Kim Sang-Ho )
가톨릭대학교 의과대학 병리학교실
심상인 ( Shim Sang-In )
가톨릭대학교 의과대학 병원병리학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 병원병리학교실
KMID : 0357920100440060581
Abstract
Background : Dendritic cells (DCs) play an important role in immune reactions. This study was designed to identify the distribution patterns of DCs and regulatory T-cells (Tregs) in cutaneous lymphomas.
Methods : Immunohistochemistry was used to determine langerin expression on Langerhans cells, CD11b on inflammatory DCs, CD209 and CD11c on dermal DCs, CD303 on plasmacytic DCs, and Foxp3 on Tregs in 81 cases of cutaneous lymphomas.
Results : Various DCs and Tregs were identified in most cutaneous lymphomas. Plasmacytic DCs, inflammatory DCs and Tregs were identified mainly in tumor areas, whereas dermal DCs were distributed both in the tumor and stromal areas. Among DCs, dermal DCs were most prominently identified in the cutaneous lymphomas not only in the tumor area but also in the stroma. The intense stromal infiltration of dermal DCs was consistent finding in T-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL), not otherwise specified also showed intense stromal infiltration of dermal DCs, but stromal infiltration in DLBCL, leg type was relatively scant.
Conclusions : The results suggest that all types of DCs and Tregs are involved in cutaneous lymphoma tumor immunity. Among them dermal DCs may play a dominant role.
키워드
Dendritic cells; T-Lymphocytes; regulatory; Lymphomas; cuta
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