한국인 성인에서 국소분절사구체경화증의 아형에 따른 분석
An Analysis of Focal Segmental Glomerulosclerosis according to Morphologic Subtypes
김민주, 김도경, 임범진, 정현주,
소속 상세정보
김민주 ( Kim Min-Ju )
연세대학교 의과대학 병리학교실
김도경 ( Kim Do-Kyung )
연세대학교 의과대학 병리학교실
임범진 ( Lim Beom-Jin )
연세대학교 의과대학 병리학교실
정현주 ( Jeong Hyeon-Joo )
연세대학교 의과대학 병리학교실
KMID : 0357920100440060589
Abstract
Background : The histological subtypes of focal segmental glomerulosclerosis (FSGS) have different significance and influence clinical presentations and outcomes in patients with FSGS. However, no such data has been reported in Korea.
Methods : We reviewed renal biopsy specimens of 69 adult patients who were diagnosed with idiopathic FSGS between 2000 and 2008, subclassified them according to the Columbia classification and correlated the results with clinical findings.
Results : The frequencies of the FSGS subtypes were not otherwise specified (NOS) (n = 28), tip (n = 21), perihilar (n = 11), collapsing (n = 5) and cellular types (n = 4) in descending order. Nephrotic syndrome was more common in patients with the tip and collapsing types than the perihilar type. The prevalence of chronic kidney disease stage 4/5 at the time of renal biopsy was significantly higher in patients with the cellular type than the NOS or the tip type. The remission rate after treatment tended to be higher in patients with the NOS type (22.0%) and the tip type (15.2%) than the perihilar (6.8%) and collapsing types (3.4%).
Conclusions : Classifying FSGS subtypes may be helpful to predict of clinical features and renal outcomes.
키워드
Glomerulosclerosis; focal segmental; Morphologic subtypes; Clinical course; Prognosis; Renal biopsy
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