폐편평세포암종에서 Oct4 발현의 임상적 의의
Clinical Implication of Oct4 Expression in Squamous Cell Carcinoma of Lung
김태정, 이연수, 이교영, 강창석,
소속 상세정보
김태정 ( Kim Tae-Jung )
가톨릭대학교 의과대학 병원병리학교실
이연수 ( Lee Youn-Soo )
가톨릭대학교 의과대학 병원병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 병원병리학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 병원병리학교실
KMID : 0357920100440060631
Abstract
Background : Octamer-4 (Oct4), a transcriptional factor involved in regulating embryonic stem cells, may play a role in tumorigenesis. Since little is known about the role of Oct4 as a prognostic factor for squamous cell carcinoma (SCC) of lung, we investigated its expression in SCC tissue and its clinicopathologic significance.
Methods : Formalin-fixed, paraffin embedded tissues from 79 patients, including 44 complete resections and 35 biopsies, obtained from 1995 to 2008 were immunostained for Oct4, scored, and scores correlated with clinicopathologic parameters and survival.
Results : Oct4 expression in tumors was significantly associated with peripheral location (vs central location) (p = 0.004) and pleural invasion (p = 0.018). In 44 complete resections, survival analysis revealed that Oct4 expression and increased stage (II and III vs I) were significantly associated with worse survival in univariate analysis (p = 0.005 and p = 0.009, respectively) and in multivariate analysis (p = 0.024 and p = 0.033, respectively).
Conclusions : The expression of Oct4 and high stage in SCC of lung are significant predictors of a poor prognosis and diminished overall survival.
키워드
Oct4; Immunohistochemistry; Lung; Squamous cell carcinoma; Prognosis
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