결막에 발생한 CK20 음성, CK7 양성 Merkel세포암종 - 짧은 증례 보고 -
CK20 Negative and CK7 Positive Merkel Cell Carcinoma of the Conjunctiva - Brief Case Report -
신정하, 박재영, 김현승, 신옥란, 이교영,
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신정하 ( Shin Jung-Ha )
가톨릭대학교 의과대학 병원병리학교실
박재영 ( Park Jae-Young )
가톨릭대학교 의과대학 인천성모병원 안과
김현승 ( Kim Hyun-Seung )
가톨릭대학교 의과대학 여의도성모병원 안과
신옥란 ( Shin Ok-Ran )
가톨릭대학교 의과대학 병원병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 병원병리학교실
KMID : 0357920100440060675
Abstract
Merkel cell carcinoma (MCC) is an uncommon but potentially aggressive neuroendocrine carcinoma of the skin. It typically develops on sun-exposed areas of the head and neck, particularly the eyelid, periorbital region, and extremities. We report a case of unusually located MCC, presenting as a conjunctival mass, which has only been reported once in the English literature. An 83-year-old male presented with a 0.8 × 0.7 cm sized mass protruding from the lower fornix of the right conjunctiva. The mass was excised. The tumor was located in the submucosa without connection to the overlying mucosa. Light microscopic findings showed a carcinoma with undifferentiated small round cells and the presence of cytokeratin (CK AE1/3, CK7) and neuroendocrine markers. We established a diagnosis of MCC. As reported in the literature, the majority of MCCs are positive for CK20 but negative for CK7. But, this case showed an uncommon cytokeratin immunohistochemical profile of positive for CK7 and negative for CK20, suggesting a new immunophenotypic MCC variant.
키워드
Carcinoma; Merkel cell; Neuroendocrine tumors; Conjunctiva
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