Prognostic Implications of the Expression of CXCL16 in Breast Carcinoma
Choi Dong-Youl, 홍란, Lim Sung-Churl, 기근홍, 서재홍, 이미자,
소속 상세정보
( Choi Dong-Youl )
Chosun University College of Medicine Department of Pathology
홍란 ( Hong Ran )
Chosun University College of Medicine Department of Pathology
( Lim Sung-Churl )
Chosun University College of Medicine Department of Pathology
기근홍 ( Kee Keun-Hong )
Chosun University College of Medicine Department of Pathology
서재홍 ( Suh Chae-Hong )
Chosun University College of Medicine Department of Pathology
이미자 ( Lee Mi-Ja )
Chosun University College of Medicine Department of Pathology
KMID : 0357920110450010015
Abstract
Background : Of the many prognostic factors for breast cancer, the relationship between an infiltration of inflammatory cells and the prognosis is debatable. Of the chemokines affecting cancer’s inflammatory reactions, chemokine (C-X-C motif) ligand 16 (CXCL16) has attracted attention for its prognostic value in many cancers, including colorectal cancer and renal cell carcinoma. But the situation for breast carcinoma is unknown. The aim of this study was to examine the relationship between the prognostic factors and the CXCL16 expression in patients with breast carcinoma.
Methods : The patients (n=106) diagnosed with invasive ductal cancer of the breast were enrolled. We reviewed the clinicopathological factors of these patients, hematoxylin and eosin stains were prepared and estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2/neu) and CXCL16 immunostaining was performed.
Results : The ER expression was significantly correlated with age and inflammation. A CXCL16 expression was noted in 81.1% of the cases. No association was evident between a CXCL16 expression and any other parameter, including the survival rate. Multivariate analysis did not implicate ER, HER2/neu or CXCL16 as an independent prognostic factor, but the tumor size was independent predictive factor for the patient outcome.
Conclusions : An inflammatory reaction mediated by CXCL16 is not associated with the prognosis of breast cancer or any clinicopathological factors.
키워드
Breast neoplasms; CXCL16 protein human; Prognosis; Survival
원문 및 링크아웃 정보
등재저널 정보