Pathologic Differences between Placentas from Intrauterine Growth Restriction Pregnancies with and without Absent or Reversed End Diastolic Velocity of Umbilical Arteries
유창영, 장동규, 조윤성, 유진영, Lee Guisera,
소속 상세정보
유창영 ( Yoo Chang-Young )
Catholic University School of Medicine Department of Pathology
장동규 ( Jang Dong-Gyu )
Catholic University School of Medicine Department of Obstetrics and Gynecology
조윤성 ( Jo Yun-Sung )
Catholic University School of Medicine Department of Obstetrics and Gynecology
유진영 ( Yoo Jin-Young )
Catholic University School of Medicine Department of Pathology
( Lee Guisera )
Catholic University School of Medicine Department of Obstetrics and Gynecology
KMID : 0357920110450010036
Abstract
Background : Abnormal umbilical artery Doppler velocimetry is one of the important findings of intrauterine growth restriction (IUGR) and IUGR is associated with high perinatal morbidity and mortality. In addition, this abnormal Doppler velocimetry is correlated with placental insufficiency. The aim of this study was to determine the pathologic differences in the placentas from IUGR pregnancies with and without the absent or reversed end diastolic velocity (AREDV).
Methods : Among the cases that had undergone prenatal follow-up in our institute, a retrospective slide review was conducted for 18 cases of IUGR with AREDV and 17 cases with IUGR that had normal end-diastolic flow of the umbilical artery.
Results : The birth weight and the other clinical parameters were not different among the two groups. Grossly, the placental wei ght percentiles were significantly smaller in AREDV group when they were adjusted according to gestational age. Histologically, chronic deciduitis, mural hypertrophy of the decidual arteries, an intimal fibrin cushion of the large fetal vessels, increased syncytial knots, villous agglutinations, avascular villi, villous stromal-vascular karyorrhexis, and acute atherosis were more frequently found in the AREDV group and their presence showed statistical significance.
Conclusions : These findings suggest that pathologic abnormalities due to fetal and maternal vasculopathies in the placenta may be the cornerstone for inducing AREDV in the umbilical artery.
키워드
Fetal growth retardation; Umbilical arteries; Doppler velocimetry; Placenta; Pathology
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