Molecular Biological Characteristics of Differentiated Early Gastric Cancer on the Basis of Mucin Expression
신나리, 김혜연, 김우경, 박민경, 김경빈, 신동훈, 최경운, 김지연, 이창훈, Huh Gi-Young, 설미영, 박도윤,
소속 상세정보
신나리 ( Shin Na-Ri )
Pusan National University College of Medicine Department of Pathology
김혜연 ( Kim Hye-Yeon )
Pusan National University College of Medicine Department of Pathology
김우경 ( Kim Woo-Kyung )
Pusan National University College of Medicine Department of Pathology
박민경 ( Park Min-Gyung )
Pusan National University College of Medicine Department of Pathology
김경빈 ( Kim Kyung-Bin )
Pusan National University College of Medicine Department of Pathology
신동훈 ( Shin Dong-Hoon )
Pusan National University College of Medicine Department of Pathology
최경운 ( Choi Kyung-Un )
Pusan National University College of Medicine Department of Pathology
김지연 ( Kim Jee-Yeon )
Pusan National University College of Medicine Department of Pathology
이창훈 ( Lee Chang-Hun )
Pusan National University College of Medicine Department of Pathology
( Huh Gi-Young )
Pusan National University School of Medicine Department of Forensic Medicine
설미영 ( Sol Mee-Young )
Pusan National University College of Medicine Department of Pathology
박도윤 ( Park Do-Youn )
Pusan National University College of Medicine Department of Pathology
KMID : 0357920110450010069
Abstract
Background : It is clear that the biologic characteristics of gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences of mucin expression in gastric cancer.
Methods : We analyzed various protein expressions and microsatellite instability (MSI) status based on mucin expression in 130 differentiated early gastric adenocarcinoma cases. Furthermore, we evaluated the genomic alternation in 10 selected differentiated early gastric adenocarcinoma cases using array based comparative genomic hybridization (aCGH).
Results : Intestinal mucin predominant subtype showed significantly elevated p53 protein and caudal-related homeobox 2 expression, and delocalization of beta catenin expressions compared to the gastric mucin predominant subtype. On MSI status, the gastric mucin predominant subtype more frequently showed unstable status than the intestinal mucin predominant subtype. CGH study showed more frequent chromosomal gain and loss in the intestinal mucin predominant subtype than the gastric mucin predominant subtype, albeit without statistical significance. Interestingly, there were significant differences in chromosomal alternation between four mucin phenotypes.
Conclusions : Study results suggest possible different points of biologic behaviors in early differentiated gastric adenocarcinomas by mucin expression type.
키워드
Stomach neoplasms; Tumor suppressor protein p53; beta catenin; Microsatellite instability; Comparative genomic hybridiza
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