Cytologic Features of Prostatic Adenocarcinoma in Urine: Comparison with Urothelial Carcinoma
김루시아, 송주영, 최석진, 박인서, 한지영, 김준미, 주영채,
소속 상세정보
김루시아 ( Kim Lucia )
Inha University College of Medicine Department of Pathology
송주영 ( Song Joo-Young )
Inha University College of Medicine Department of Pathology
최석진 ( Choi Suk-Jin )
Inha University College of Medicine Department of Pathology
박인서 ( Park In-Suh )
Inha University College of Medicine Department of Pathology
한지영 ( Han Jee-Young )
Inha University College of Medicine Department of Pathology
김준미 ( Kim Joon-Mee )
Inha University College of Medicine Department of Pathology
주영채 ( Chu Young-Chae )
Inha University College of Medicine Department of Pathology
KMID : 0357920110450010079
Abstract
Background : Prostate adenocarcinoma (PACa) cells are rarely identified in urine cytology specimens and might be easily overlooked or misdiagnosed as urothelial neoplasm when clinically unsuspected.
Methods : We reviewed 19 urine cytology specimens obtained from 13 patients with PACa and evaluated the characteristic features discriminating PACa from urothelial carcinoma (UCa). For comparison, 27 cases of high-grade UCa (HGUCa) and 10 cases of urothelial carcinoma in situ (UCis) were also evaluated.
Results : The urine cytologic evaluation of PACa revealed clustered cells forming 3-dimensional syncytial fragments with occasional microacinar grouping in a clean background. Most tumor cells were small and uniform with a high nuclear-to-cytoplasmic ratio and indistinct cell borders. The nuclei were round-to-oval and the cytoplasm was scanty and thin. One or more centrally-located prominent nucleoli were characteristically noted in one half of the cases. The nucleoli had a well-defined, large, round and eosinophilic appearance. In four high-grade cases, large tumor cells were encountered and had relatively monotonous cells with smooth-outlined cell clusters, well-defined and thin cytoplasm, and round nuclei with characteristic prominent nucleoli.
Conclusions : Combining the information of prostate cancer and the recognition of cytomorphologic features of PACa will help differentiate PACa from HGUCa and UCis.
키워드
Prostatic neoplasms; Urine; Cytology; Carcinoma; transitional cell
원문 및 링크아웃 정보
등재저널 정보