Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen - A Case Report -
이현정, 최송이, Huang Song-Mei, 설지영, 김진만,
소속 상세정보
이현정 ( Lee Hyun-Jung )
Chungnam National University College of Medicine Department of Pathology
최송이 ( Choi Song-Yi )
Chungnam National University College of Medicine Department of Pathology
( Huang Song-Mei )
Chungnam National University College of Medicine Department of Pathology
설지영 ( Sul Ji-Young )
Chungnam National University School of Medicine Department of Surgery
김진만 ( Kim Jin-Man )
Chungnam National University College of Medicine Department of Pathology
KMID : 0357920110450010111
Abstract
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT in the spleen with its pathologic features, and review the related literature. A 50-year-old woman presented with mild left upper quadrant discomfort and tenderness and she showed a 6 cm-sized solitary splenic mass on computed tomography. She underwent laparoscopic splenectomy. Grossly, the spleen showed a well circumscribed round-shaped solid mass with multinodular hemorrhagic surfaces. Microscopically, the mass consisted of multiple angiomatoid nodules surrounded by collagen bundles with fibroblasts and a lymphoplasma cell infiltration. Immunohistochemically, the cells of the angiomatoid nodules were positive for CD31, CD30, CD34, alpha-smooth muscle actin, and VWF-VIII, but they were negative for CD8, anaplastic lymphoma kinase protein, and D2-40. The patient has been under close follow-up without recurrence.
키워드
Spleen; Hamartoma; Antigens; CD31
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