Immunohistochemical Identification of Pneumocystis jirovecii in Liquid-based Cytology of Bronchoalveolar Lavage - Nine Cases Report -
이정현, 이지영, 신미란, Ahn Hyeong-Kee, 김철환, 김인선,
소속 상세정보
이정현 ( Lee Jeong-Hyeon )
Korea University College of Medicine Department of Pathology
이지영 ( Lee Ji-Young )
Korea University College of Medicine Department of Pathology
신미란 ( Shin Mi-Ran )
Korea University College of Medicine Department of Pathology
( Ahn Hyeong-Kee )
Korea University College of Medicine Department of Pathology
김철환 ( Kim Chul-Whan )
Korea University College of Medicine Department of Pathology
김인선 ( Kim In-Sun )
Korea University College of Medicine Department of Pathology
KMID : 0357920110450010115
Abstract
Pneumocystis pneumonia (PCP) is caused by the yeast-like fungus Pneumocystis jirovecii, which is specific to humans. PCP could be a source of opportunistic infection in adults that are immunosuppressed and children with prematurity or malnutrition. The diagnosis should be confirmed by identification of the causative organism, by analysis of the sputum, a bronchoalveolar lavage or a tissue biopsy. In both histologic and cytologic specimens, the cysts are contained within frothy exudates, which form aggregated clumps. The cysts often collapse forming crescent-shaped bodies that resemble ping-pong balls. We recently diagnosed nine cases of PCP using an immunohistochemical stain for Pneumocystis. The patients consisted of five human immunodeficiency virus positive individuals, two renal transplant recipients, and two patients with a malignant disease. All nine patients were infected with P. jirovecii, which was positive for monoclonal antibody 3F6. In conclusion, the immunohistochemical stain used in this report is a new technique for the detection of P. jirovecii infection.
키워드
Pneumocystis jirovecii; Bronchoalveolar lavage; Immunohistochemistry
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