Cytologic Findings of Alveolar Soft Part Sarcoma Presenting with Multiple Pulmonary Masses - A Case Report with Review of Literature -
김나래, 노재윤, 조은경, 김미진, 안준석, 하승연,
소속 상세정보
김나래 ( Kim Na-Rae )
Gachon University Gil Hospital Department of Pathology
노재윤 ( Ro Jae Y. )
Weill Medical College of Cornell University The Methodist Hospital Department of Pathology
조은경 ( Cho Eun-Kyung )
Gachon University Gil Hospital Department of Hematooncology
김미진 ( Kim Mi-Jin )
Yeungnam University College of Medicine Department of Pathology
안준석 ( An Jung-Suk )
Gachon University Gil Hospital Department of Pathology
하승연 ( Ha Seung-Yeon )
Gachon University Gil Hospital Department of Pathology
KMID : 0357920110450010119
Abstract
Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor of uncertain origin, and it has a strong propensity for metastasis to the lungs, bones and brain. We report upon an unusual case of ASPS, presenting as multiple lung nodules with no other detectable primary site, in a 44-year-old man. A fine needle aspiration of the nodules yielded scattered, discohesive cells, each containing an eccentrically displaced nucleus and prominent nucleolus, on a granular background. Tumor cells with numerous bared nuclei, and occasional sheets of epithelioid cells were also found. Under the cytological diagnosis of an unclassified epithelioid malignant tumor, resection of the lung nodules was performed. The histologic findings were consistent with ASPS, showing positive TFE3-nuclear immunoreactivity. There is limited literature concerning cytological findings associated with pulmonary ASPS: especially in cases where the primary site is unknown. Here, we present a cytological review of pulmonary ASPS, investigating the significance of TFE3 staining in the diagnosis of ASPS.
키워드
Sarcoma; alveolar soft part; Lung; Biopsy; fine needle; Neoplasm metastasis; TFE3 stain
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