초음파 유도 갑상샘 세침흡인세포검사에서 CellprepPlus® 액상세포검사: 고식적 도말검사와 CellprepPlus® 액상세포검사와의 비교
CellprepPlus® Liquid-based Smear in Sono-guided Thyroid Fine Needle Aspiration: A Comparison of Conventional Method and CellprepPlus® Liquid-based Cytology
구지혜, 이승영, 이호창, 박진우, 궁성수, 오태근, 전황균, 김은중, 이옥준,
소속 상세정보
구지혜 ( Koo Ji-Hae )
충북대학교 의과대학 병리학교실
이승영 ( Lee Seung-Young )
Chungbuk National University
이호창 ( Lee Ho-Chang )
충북대학교 의과대학 병리학교실
박진우 ( Park Jin-Woo )
Chungbuk National University
궁성수 ( Koong Sung-Soo )
Chungbuk National University
오태근 ( Oh Tae-Geun )
Chungbuk National University
전황균 ( Jeon Hwang-Gyun )
Chungbuk National University
김은중 ( Kim Eun-Joong )
주성대학교 임상병리학교실
이옥준 ( Lee Ok-Jun )
충북대학교 의과대학 병리학교실
KMID : 0357920110450020182
Abstract
Background : Fine needle aspiration (FNA) of the thyroid is a useful tool for the evaluation of benign or malignant thyroid nodules. The improvements in the quality of cytological preparations using the liquid-based cytology (LBC) method have been well-documented. The principal objective of this study was designed to evaluate the diagnostic adequacy, sensitivity, and specificity of the thyroid FNA comparing a conventional smear with the LBC adapted with the filtration method described herein.
Methods : One hundred ninety eight cases of FNA samples obtained from May 2009 to September 2009 were included in this study. All patients were subjected to ultrasound-guided aspiration twice at a target lesion by a radiologist and two types of slides were prepared using conventional smear and LBC.
Results : When compared with conventional method, the cellularity was reduced in LBC. However, the malignant tumor cells evidenced the larger and more vesicular nuclei, prominent nucleoli, and distinct nuclear membranes in LBC. Thirty two cases (16.16%) of conventional smear were inadequate, but 96 cases (48.49%) of LBC were inadequate.
Conclusions : Most of the slides using CellprepPlus® LBC evidenced lower cellularity and clearer background. However, the conventional smears were found to generate much more applicable samples than CellprepPlus® LBC.
키워드
Thyroid; Cytology; Aspiration
원문 및 링크아웃 정보
등재저널 정보