A Metastatic Granulocyte Colony-Stimulating Factor Producing Sarcomatoid Carcinoma of the Lung Causing Jejunal Intussusception - Report of a Case -
홍민의, 홍순억, 권귀영, 이태진, 박언섭, 차성재, 도재혁, 유재형,
소속 상세정보
홍민의 ( Hong Min-Eui )
Chung-Ang University College of Medicine Department of Pathology
홍순억 ( Hong Soon-Auck )
Chung-Ang University College of Medicine Department of Pathology
권귀영 ( Kwon Gui-Young )
Chung-Ang University College of Medicine Department of Pathology
이태진 ( Lee Tae-Jin )
Chung-Ang University College of Medicine Department of Pathology
박언섭 ( Park Eon-Sub )
Chung-Ang University College of Medicine Department of Pathology
차성재 ( Cha Sung-Jae )
Chung-Ang University College of Medicine Department of General Surgery
도재혁 ( Do Jae-Hyuk )
Chung-Ang University College of Medicine Department of Internal Medicine
유재형 ( Yoo Jae-Hyung )
Chung-Ang University College of Medicine Department of Pathology
KMID : 0357920110450020205
Abstract
A 75-year-old man was referred to our hospital with intestinal obstruction caused by intussusception. Abdominal computed tomography (CT) revealed seven polypoid masses in the small intestine, while chest CT revealed a mass in the right lower lobe. Preoperative laboratory tests showed white blood cell (WBC) and neutrophil differential counts of 63,630/mm³ and 95%, respectively. The serum granulocyte colony-stimulating factor (G-CSF) was 114 pg/mL, which was elevated (normal range, <18.1 pg/mL). After resection of the small bowel, the WBC count decreased to 20,510/mm³. The pathology showed a poorly differentiated carcinoma with sarcomatous components confirmed by positive immunostaining of cytokeratin (AE1/AE3) and vimentin in the small intestine. Furthermore, immunohistochemistry with specific monoclonal antibodies against G-CSF was positive. A lung biopsy revealed the same histological findings as the small intestine lesion. Therefore, the patient was diagnosed as having a G-CSF producing sarcomatoid carcinoma of the lung with metastasis to the small intestine.
키워드
Carcinosarcoma; Granulocyte colony-stimulating factor; Metastasis; Intussusception
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