피부 멜라닌세포질환에서 악성 진행에 따른 세포자멸사 관련 단백들(Apaf-1, Caspase-9, Bcl-2, p53, and Survivin)의 변화
Alteration of Apoptosis-Related Proteins (Apaf-1, Caspase-9, Bcl-2, p53, and Survivin) According to Malignant Progression in Cutaneous Melanocytic Lesions
강여주, 정지한, 임광일, 이교영, 이연수, 강석진, 강창석, 김시용,
소속 상세정보
강여주 ( Kang Yeo-Ju )
가톨릭대학교 의과대학 병원병리학교실
정지한 ( Jung Ji-Han )
가톨릭대학교 의과대학 병원병리학교실
임광일 ( Yim Kwang-Il )
가톨릭대학교 의과대학 병원병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 병원병리학교실
이연수 ( Lee Youn-Soo )
가톨릭대학교 의과대학 병원병리학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 병원병리학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 병원병리학교실
김시용 ( Kim Si-Yong )
가톨릭대학교 의과대학 피부과학교실
KMID : 0357920110450030247
Abstract
Background : Apoptosis protease activating factor-1 (Apaf-1), caspase-9, Bcl-2, p53, and survivin are important factors in the pathway of apoptosis, but their clinicopathologic significance remains unclear in human cutaneous melanoma. We investigated the expression of these proteins and their clinical value in human cutaneous melanocytic lesions.
Methods : We performed an immunohistochemical analysis to examine the expression and distribution of Apaf-1, caspase-9, Bcl-2, p53, and survivin in 36 cases of malignant melanoma (22 cases of primary melanoma and 14 cases of metastatic melanoma) and 41 cases of melanocytic nevus.
Results : The expression of p53 was significantly higher in malignant melanoma than in melanocytic nevus (p<0.01), however the expressions of Apaf-1 and caspase-9 were significantly lower in malignant melanoma compared with melanocytic nevus (p<0.01 and p=0.027, respectively). Also, there was a significant difference for Bcl-2 staining between primary melanomas and metastatic lesions (p=0.004). Nuclear staining for survivin were absent in nevus, but were positive in 14 of 36 melanomas (p<0.01).
Conclusions : The altered expression of Apaf-1, caspase-9, p53, and survivin are considered to be related to malignant progression in human cutaneous melanocytic lesions. Loss of Bcl-2 can be considered as a prognostic marker of malignant melanomas.
키워드
Apaf-1; Caspase-9; Bcl-2; p53; Survivin; Malignant melanoma
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