WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study
김진만, 고영혜, 이승숙, 허주령, 강창석, 김철우, 강윤경, 고재향, 김민경, 김완섭, 김윤정, 김현정, 김희경, 남종희, 문형배, 박찬금, 박태인, 오영하, 이동화, 이종실, 이주희, 이혜경, 임성철, 장규윤, 장희경, 전윤경, 정혜라, 조민선, 차희정, 최석진, 한재호, 홍숙희, 김인선,
소속 상세정보
김진만 ( Kim Jin-Man )
Chungnam National University College of Medicine Department of Pathology
고영혜 ( Ko Young-Hyeh )
Samusng Medical Center Department of Pathology
이승숙 ( Lee Seung-Sook )
Korea Cancer Center Hospital Department of Pathology
허주령 ( Huh Joo-Ryung )
University of Ulsan College of Medicine Department of Pathology
강창석 ( Kang Chang-Suk )
Catholic University College of Medicine Department of Pathology
김철우 ( Kim Chul-Woo )
Seoul National University College of Medicine Department of Pathology
강윤경 ( Kang Yun-Kyung )
Seoul Paik Hospital Department of Pathology
고재향 ( Go Jai-Hyang )
Dankook University College of Medicine Department of Pathology
김민경 ( Kim Min-Kyung )
Kangbuk Samsung Hospital Department of Pathology
김완섭 ( Kim Wan-Seop )
Konkuk University College of Medicine Department of Pathology
김윤정 ( Kim Yoon-Jung )
Seoul Veterans Hospital Department of Pathology
김현정 ( Kim Hyun-Jung )
Sanggye Paik Hospital Department of Pathology
김희경 ( Kim Hee-Kyung )
Soonchunhyang University Bucheon Hospital Department of Pathology
남종희 ( Nam Jong-Hee )
Chonnam National University Medical School Department of Pathology
문형배 ( Moon Hyung-Bae )
Wonkwang University School of Medicine Department of Pathology
박찬금 ( Park Chan-Kum )
Hanyang University College of Medicine Department of Pathology
박태인 ( Park Tae-In )
Kyungpook National University School of Medicine Department of Pathology
오영하 ( Oh Young-Ha )
Hanyang University Guri Hospital Department of Pathology
이동화 ( Lee Dong-Wha )
Soonchunhyang University College of Medicine Department of Pathology
이종실 ( Lee Jong-Sil )
Gyeongsang National University College of Medicine Department of Pathology
이주희 ( Lee Ju-Hie )
Kyung Hee University School of Medicine Department of Pathology
이혜경 ( Lee Hye-Kyung )
Eulji University School of Medicine Department of Pathology
임성철 ( Lim Sung-Chul )
Chosun University College of Medicine Department of Pathology
장규윤 ( Jang Kyu-Yun )
Chonbuk National University Medical School Department of Pathology
장희경 ( Chang Hee-Kyung )
Kosin University College of Medicine Department of Pathology
전윤경 ( Jeon Yoon-Kyung )
Seoul National University College of Medicine Department of Pathology
정혜라 ( Jung Hye-Ra )
Keimyung University College of Medicine Department of Pathology
조민선 ( Cho Min-Sun )
Ewha Womans University College of Medicine Department of Pathology
차희정 ( Cha Hee-Jeong )
University of Ulsan College of Medicine Department of Pathology
최석진 ( Choi Suk-Jin )
Inha University College of Medicine Department of Pathology
한재호 ( Han Jae-Ho )
Ajou University School of Medicine Department of Pathology
홍숙희 ( Hong Sook-Hee )
Dong-A University College of Medicine Department of Pathology
김인선 ( Kim In-Sun )
Korea University College of Medicine Department of Pathology
KMID : 0357920110450030254
Abstract
Background : The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea.
Methods : A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained.
Results : The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was no-dular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed.
Conclusions : Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Wes-tern countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.
키워드
Lymphoma; Malignant; WHO; Korea
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