Composite Pheochromocytoma or Paraganglioma of Adrenal Gland: A Case Report with Immunohistochemical Studies and Electron Microscopic Examination
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ÀåÇýÀ± ( Chang Hye-Yoon )
Korea University College of Medicine Department of Pathology
Á¤È¸¼± ( Jeong Hoi-Seon )
Korea University College of Medicine Department of Pathology
±è¿µÇý ( Kim Young-Hye )
Korea University College of Medicine Department of Pathology
¹Ú¼ºÇý ( Park Sung-Hye )
Seoul National University College of Medicine Department of Pathology
±è¾Ö¸® ( Kim Ae-Ree )
Korea University College of Medicine Department of Pathology
KMID : 0357920110450030306
Abstract
Composite pheochromocytoma or paraganglioma of the adrenal gland is a well-recognized, yet extremely rare tumor with only one case reported in Korea. We report a case of incidentally found composite pheochromocytoma and ganglioneuroma of the adrenal gland in a 44-year-old female composed of intermingled components of pheochromocytom, ganglioneuroma, and cells with intermediate features. On immunohistochemical staining, the pheochromocytoma component was positive for synaptophysin and chromogranin, but negative for S-100 protein. Staining for the S-100 protein revealed sustentacular cells which formed a peripheral coat around the ¡°Zellballen¡± and Schwann cells. The Fontana-Masson stain defined neuromelanin granules of ganglion cells and the ganglion cells expressed neural markers such as neurofilament proteins. Ultrastructural findings revealed pheochromocytes with a round or ovoid nucleus and occasionally prominent nucleolus containing numerous adrenaline and noradrenaline granules.
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Composite pheochromocytoma and ganglioneuroma; Pheochromocytoma; Paraganglioma; Adrenal glands
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