Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings
김나래, 노재윤, 신경환, 백혜정, 안준석, 하승연,
소속 상세정보
김나래 ( Kim Na-Rae )
Gachon University Gil Hospital Department of Pathology
노재윤 ( Ro Jae Y. )
Weill Medical College of Cornell University The Methodist Hospital Department of Pathology
신경환 ( Shin Kyung-Hwan )
Gachon University Gil Hospital Department of Ophthalmology
백혜정 ( Paik Hae-Jung )
Gachon University Gil Hospital Department of Ophthalmology
안준석 ( An Jung-Suk )
Gachon University Gil Hospital Department of Pathology
하승연 ( Ha Seung-Yeon )
Gachon University Gil Hospital Department of Pathology
KMID : 0357920110450030315
Abstract
A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
키워드
Solitary fibrous tumors; Conjunctiva; Antigens; CD34; CD99; Bcl-2
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