Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer
유설봉, Xu Xianhua, 최기영, 정진행, 이현주, 전상훈, 이춘택,
소속 상세정보
유설봉 ( Yoo Seol-Bong )
Seoul National University Bundang Hospital Department of Pathology
( Xu Xianhua )
Seoul National University Bundang Hospital Department of Pathology
최기영 ( Choe Ghee-Young )
Seoul National University Bundang Hospital Department of Pathology
정진행 ( Chung Jin-Haeng )
Seoul National University Bundang Hospital Department of Pathology
이현주 ( Lee Hyun-Ju )
Soonchunhyang University College of Medicine Soonchunhyang University Cheonan Hospital Department of Pathology
전상훈 ( Jheon Sang-Hoon )
Seoul National University College of Medicine Department of Thoracic and Cardiovascular Surgery
이춘택 ( Lee Choon-Taek )
Seoul National University College of Medicine Department of Internal Medicine
KMID : 0357920110450040329
Abstract
Background: Alterations in the phosphatase and tensin homolog (PTEN) are correlated with tumor progression. Downregulation of PTEN is related to drug resistance of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the prognostic significance of PTEN in patients with NSCLC and its correlation with EGFR.
Methods: Two hundred eighty eight surgically resected NSCLC samples, including 168 adenocarcinomas (ADCs), 99 squamous cell carcinomas (SCCs) and 21 other NS-CLCs were analyzed for the PTEN. The results were correlated with other clinicopathological variables including EGFR amplification and mutation.
Results: Loss of PTEN was detected in 42.4% of NSCLCs, specifically 28.6% of ADCs, 66.7% of SCCs, and 38.1% of others. Loss of PTEN was significantly associated with SCC, smoking, male gender, and higher stage. In a multivariate analysis, loss of PTEN was significantly associated with short progression-free survival (p=0.037). No association between PTEN and EGFR was observed.
Conclusions: These results suggest that loss of PTEN results in shorter progression-free survival in patients with NSCLC, and loss of PTEN is more associated with SCC, smoking, male gender, and higher T stage by the 7th tumor, node and metastasis staging system but not EGFR status.
키워드
PTEN;Carcinoma;non-small-cell;Immunohistochemistry;Prognosis
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