Human Papillomavirus Prevalence in Gangwon Province Using Reverse Blot Hybridization Assay
이동섭, 김성현, 박상정, 진현우, 김태우, 이혜영, 박광하,
소속 상세정보
이동섭 ( Lee Dong-Sup )
연세대학교 보건과학대학 임상병리학과
김성현 ( Kim Sung-Hyun )
연세대학교 보건과학대학 임상병리학과
박상정 ( Park Sang-Jung )
연세대학교 보건과학대학 임상병리학과
진현우 ( Jin Hyun-Woo )
연세대학교 보건과학대학 임상병리학과
김태우 ( Kim Tae-Ue )
연세대학교 보건과학대학 임상병리학과
이혜영 ( Lee Hye-Young )
연세대학교 보건과학대학 임상병리학과
박광하 ( Park Kwang-Hwa )
연세대학교 원주의과대학 병리학교실
KMID : 0357920110450040348
Abstract
Background: Human papillomavirus (HPV) plays an important role in the development of cervical carcinoma. Although there is a general agreement that high levels of HPV are related to cervical cancer, the prevalence and distribution of HPV genotypes seems to vary by geographical region. This study was designed to investigate the prevalence of HPV genotypes in Gangwon Province, Korea.
Methods: In total, 342 samples were examined by Pap smear and HPV-ID® reverse blot hybridization assay (REBA) (M&D, Wonju, Korea).
Results: Overall HPV positivity was 80.9% and 64.4% in women with abnormal and normal cytology by REBA, respectively. The five most common HPV types were: HPV 16, 53, 58, 56, and 33 in samples with abnormal cytology, and HPV 16, 53, 58, 70, and 18 in samples with normal cytology.
Conclusions:The REBA can provide useful data regarding prevalence of HPV genotypes. Gangwon Province showed high prevalence of HPV infection in women. The most common HPV type in Gangwon Province was HPV16, and HPV 53, 58, 56, 70 were frequently present.
키워드
Human papillomavirus;Prevalence;Uterine cervical neoplasms;Reverse blot hybridization assay;Gangwon Province
원문 및 링크아웃 정보
등재저널 정보