Insulin-like Growth Factor II mRNA-Binding Protein 3 Expression in Benign and Premalignant Lesions and Carcinomas of the Stomach
송대현, 양정욱, 김동철, 이종실, 이정희, 정상호,
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송대현 ( Song Dae-Hyun )
Gyeongsang National University School of Medicine Department of Pathology
양정욱 ( Yang Jung-Wook )
Gyeongsang National University School of Medicine Department of Pathology
김동철 ( Kim Dong-Chul )
Gyeongsang National University School of Medicine Department of Pathology
이종실 ( Lee Jong-Sil )
Gyeongsang National University School of Medicine Department of Pathology
이정희 ( Lee Jeong-Hee )
Gyeongsang National University School of Medicine Department of Pathology
정상호 ( Jeong Sang-Ho )
Gyeongsang National University School of Medicine Department of Surgery
KMID : 0357920110450040379
Abstract
Background: Recent studies have demonstrated that insulin-like growth factor II mRNA-binding protein 3 (IMP3) is expressed in malignant tumors of various organs but not in normal tissue. We investigated IMP3 expression in various benign lesions, premalignant lesions and carcinomas of the stomach.
Methods: IMP3 immunohistochemical staining was performed on 24 benign gastric lesions, 24 gastric adenomas, and 322 gastric carcinomas.
Results: IMP3 was not expressed in benign gastric lesions including adenomas with low-grade dysplasia, but was expressed in 17% of adenomas with high-grade dysplasia, and in 44% of carcinomas. As the carcinomas were in the advanced stage, they expressed IMP3 more frequently and strongly. Patients with IMP3-positive tumors had poorer survival than those with negative tumors.
Conclusions: IMP3 expression in gastric carcinoma may be related to tumor invasion and metastasis, and is an independent risk factor for poor prognosis.
키워드
Stomach;Carcinoma;Adenoma;IMP3 protein
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