Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma
이경화, 이제혁, Lee Soong, 이현민, Back Seung-Chul, 조성범,
소속 상세정보
이경화 ( Lee Kyung-Hwa )
Chonnam National University Medical School Department of Pathology
이제혁 ( Lee Jae-Hyuk )
Chonnam National University Medical School Department of Pathology
( Lee Soong )
Seonam University College of Medicine Department of Internal Medicine
이현민 ( Lee Hyeon-Min )
Seonam University College of Medicine Department of Internal Medicine
( Back Seung-Chul )
Seonam University College of Medicine Department of Internal Medicine
조성범 ( Cho Sung-Bum )
Chonnam National University Medical School Department of Internal Medicine
KMID : 0357920110450040397
Abstract
Background: The expression of the inhibitor of apoptosis proteins (IAPs) family has not been fully investigated in colorectal carcinomas. This study investigated IAP expression in colorectal carcinomas and assessed their prognostic significance.
Methods: Livin, XIAP, and SMAC/DIABLO expression was assessed by immunohistochemistry in 159 colorectal carcinomas. Correlations between protein expression and clinicopathological features were evaluated. The survival data analysis was estimated according to the Kaplan-Meier method.
Results: Increased expression of IAPs in cancer tissues compared to surrounding nonneoplastic counterparts was observed in 67 cases (42.1%) for Livin, 50 cases (31.4%) for XIAP, and 68 cases (42.8%) for SMAC. A significant correlation was found between Livin expression and tumor differentiation, and SMAC expression and tumor location. The recurrence-free and overall survival of patients with low Livin expression were inferior to those of patients with high Livin expression (p=0.054 and 0.095, respectively). High XIAP expression was significantly associated with shorter progression-free survival (p= 0.041).
Conclusions: Our study demonstrated that altered expression of IAP family members, including Livin, XIAP, and SMAC, is frequent in colorectal carcinoma. This result suggests that high Livin expression and low XIAP expression may be a favorable prognostic implication related to patient survival.
키워드
Inhibitor of apoptosis proteins;X-linked inhibitor of apoptosis protein;DIABLO protein;human;Colorectal neoplasms;Prognosis
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