The Stromal Overexpression of Decay Accelerating Factor (DAF/CD55) Correlates with Poor Clinical Outcome in Colorectal Cancer Patients
백태화, 김주헌, 박미자, 이혜경, 손현진, Soon Hyun-Ki, 강동욱, 김창남, 고제명,
소속 상세정보
백태화 ( Baek Tae-Hwa )
Eulji University School of Medicine Department of Pathology
김주헌 ( Kim Joo-Heon )
Eulji University School of Medicine Department of Pathology
박미자 ( Park Mee-Ja )
Eulji University School of Medicine Department of Pathology
이혜경 ( Lee Hye-Kyung )
Eulji University School of Medicine Department of Pathology
손현진 ( Son Hyun-Jin )
Eulji University School of Medicine Department of Pathology
( Soon Hyun-Ki )
Eulji University School of Medicine Department of Pathology
강동욱 ( Kang Dong-Wook )
Eulji University School of Medicine Department of Pathology
김창남 ( Kim Chang-Nam )
Eulji University School of Medicine Department of Surgery
고제명 ( Ko Che-Myong )
USA University of lllinois at Urbana-Champaign College of Veterinary Medicine
KMID : 0357920110450050445
Abstract
Background: Decay accelerating factor (DAF/CD55), regulates the complement system by accelerating decay of the C3 convertase, has been described in several malignancies, however, the clinicopathologic significance of CD55 and its receptor CD97 has not been fully investigated. We examined the expression patterns of both CD55 and CD97 and their association with clinicopathologic parameters in colorectal cancers (CRCs).
Methods: Expression patterns of CD55 and CD97 in the stroma and tumor cells at tumor center and invasive front were examined in 130 CRCs, and their significance was statistically evaluated.
Results: CD55-high stroma was correlated with tumor border (p=0.006) and invasion depth (p=0.013). CD55-high tumor cells at tumor center and invasive front were correlated with histologic grade, and CD55-high tumor cells at invasive front with tumor, node and metastasis (TNM) stage (p<0.05). CD97-high stroma was correlated with lymph node metastasis (p=0.016) and TNM stage (p=0.030). CD97-high tumor cells at tumor center and invasive front were correlated with tumor size and CD97-high tumor cells at tumor center with tumor border (p<0.05). Patients with CD55-high stroma showed poor overall and recurrence-free survival (p<0.05) in univariate analysis, and were independently associated with short recurrence-free survival (p=0.025) in multivariate analysis.
Conclusions: Stromal CD55 overexpression would be an indicator of adverse clinical outcome and a useful prognostic factor.
키워드
Decay accelerating factor (DAF/CD55); CD97;Colorectal cancers;Immunohistochemistry;Prognostic factor
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