Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas
김나래, 채양석, 임원정, 조성진,
소속 상세정보
김나래 ( Kim Na-Rae )
Gachon University Gil Hospital Department of Pathology
채양석 ( Chae Yang-Seok )
Korea University College of Medicine Department of Pathology
임원정 ( Lim Weon-Jeong )
Ewha Womans University School of Medicine Department of Neurochiatry
조성진 ( Cho Seong-Jin )
Hallym University College of Medicine Department of Pathology
KMID : 0357920110450050463
Abstract
Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs.
Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases).
Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034).
Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.
키워드
Hepatocyte growth factor;c-met;Meningioma;Neoplasm recurrence;local;Reverse transcription polymerase chain reaction
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