14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients
Moon Ahrim, 나기용, 김윤화, 박용구, 김수강, 정주호, Olvi Liliana G., Araujo Eduardo Santini,
소속 상세정보
( Moon Ahrim )
Kyung Hee University School of Medicine Department of Pathology
나기용 ( Na Ki-Yong )
Kyung Hee University School of Medicine Department of Pathology
김윤화 ( Kim Youn-Wha )
Kyung Hee University School of Medicine Department of Pathology
박용구 ( Park Yong-Koo )
Kyung Hee University School of Medicine Department of Pathology
김수강 ( Kim Su-Kang )
Kyung Hee University School of Medicine Department of Pharmacology
정주호 ( Chung Joo-Ho )
Kyung Hee University School of Medicine Department of Pharmacology
( Olvi Liliana G. )
Argentina University of Buenos Aires School of Medicine Laboratory of Orthopaedic Pathology
( Araujo Eduardo Santini )
Argentina University of Buenos Aires School of Medicine Laboratory of Orthopaedic Pathology
KMID : 0357920110450050485
Abstract
Background: The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma.
Methods: Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction.
Results: There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002).
Conclusions: The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.
키워드
HLA-G;14-bp insertion/deletion polymorphism;Osteosarcoma
원문 및 링크아웃 정보
등재저널 정보