Prognostic Implication of Programmed Death-1-Positive Tumor-infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma
°í¿µ½Å, ¿À¿µÇÏ, ¹ÚÂù±Ý, ±è¿í¿¬, ÇÑÇý½Â, ÀÓ¼Ò´ö, Ȳż÷, ±è¿Ï¼·,
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°í¿µ½Å ( Ko Young-Sin )
Konkuk University College of Medicine Department of Pathology
¿À¿µÇÏ ( Oh Young-Ha )
Hanyang University Guri Hospital Department of Pathology
¹ÚÂù±Ý ( Park Chan-Kum )
Hanyang University College of Medicine Department of Pathology
±è¿í¿¬ ( Kim Wook-Youn )
Konkuk University College of Medicine Department of Pathology
ÇÑÇý½Â ( Han Hye-Seung )
Konkuk University College of Medicine Department of Pathology
ÀÓ¼Ò´ö ( Lim So-Dug )
Konkuk University College of Medicine Department of Pathology
Ȳż÷ ( Hwang Tae-Sook )
Konkuk University College of Medicine Department of Pathology
±è¿Ï¼· ( Kim Wan-Seop )
Konkuk University College of Medicine Department of Pathology
KMID : 0357920110450060573
Abstract
Background : Programmed death-1 (PD-1) is physiologically expressed by germinal center-associated helper T-cells and has an inhibitory effect on T-cell activity.
Methods : We examined 63 cases of diffuse large B-cell lymphoma (DLBCL) and determined the number of PD-1-positive helper T-cells in a representative tumor area after immunohistochemical staining using a monoclonal antibody against PD-1. The PD-1-positive cells were counted in 3 high-power fields (HPFs; 400¡¿).
Results : Patients were divided into 2 groups: one with a high number of PD-1-positive cells (>20/HPF, n=33) and one with a low number of PD-1-positive cells (¡Â20/HPF, n=30). The former group showed decreased overall survival, but at a statistically non-significant level (p=0.073). A high number of PD-1-positive cells was more common in patients at an advanced clinical stage and with high international prognostic index score (p=0.025 and p=0.026, respectively). The number of extranodal sites also somewhat correlated with the PD-1 staining status (p=0.071). However, the number of PD-1-positive cells was not associated with patient age, serum lactate dehydrogenase level, and Eastern Cooperative Oncology Group performance score.
Conclusions : The high number of PD-1-positive cells might be associated with an unfavorable outcome in DLBCL patients.
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Lymphoma; large B-cell; diffuse; Programmed death-1 (PD-1); Lymphoma; Prognostic factor
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