Prognostic Significance of Amplification of the c-MYC Gene in Surgically Treated Stage IB-IIB Cervical Cancer
김태정, 이아원, 이성종, 이원철, 최영진, 이교영, 강창석,
소속 상세정보
김태정 ( Kim Tae-Jung )
Catholic University College of Medicine Department of Hospital Pathology
이아원 ( Lee Ah-Won )
Catholic University College of Medicine Department of Hospital Pathology
이성종 ( Lee Sung-Jong )
Catholic University College of Medicine Department of Obstetrics and Gynecology
이원철 ( Lee Won-Chul )
Catholic University College of Medicine Department of Preventive Medicine
최영진 ( Choi Yeong-Jin )
Catholic University College of Medicine Department of Hospital Pathology
이교영 ( Lee Kyo-Young )
Catholic University College of Medicine Department of Hospital Pathology
강창석 ( Kang Chang-Suk )
Catholic University College of Medicine Department of Hospital Pathology
KMID : 0357920110450060596
Abstract
Background : Mutations of c-MYC have been described in cervical cancer. However, association between c-MYC gene status and its prognostic significance have not been clarified.
Methods : Tissue microarray sections from 144 patients with stage IB-IIB cervical cancer treated by radical hysterectomy were analyzed by fluorescence in situ hybridization using a region-specific probe for c-MYC and a centromere-specific probe for chromosome 8.
Results : Seventy five percent (108/144) of c-MYC gain and 6.9% (10/144) of c-MYC gene amplification were observed. c-MYC gene alteration was more frequently observed in squamous cell carcinoma than adenocarcinoma or adenosquamous carcinoma and were associated with low Ki67 labeling index (p=0.013). c-MYC amplification was not associated with clinicopathologic parameters except absence of bcl2 expression (p=0.048). Survival analysis revealed that patients with c-MYC amplification were significantly associated with higher risk of disease recurrence (p=0.007) and cancer related death (p=0.020). However, c-MYC gain was not associated with unfavorable outcome. Multivariate analysis proved c-MYC amplification as independent prognostic factors of shorter disease free survival and cancer-related death (p=0.028 and p=0.025, respectively).
Conclusions : c-MYC amplification, not gain, is an independent prognostic marker for shorter disease free and cancer specific survival in cervical cancer treated by radical hysterectomy.
키워드
Uterine cervical neoplasms; In situ hybridization; fluorescence; MYC; Hysterectomy; Prognosis
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