Cervical Cytologic Smears in Pap Solution vs ThinPrep: Smear Characteristics and Diagnostic Agreement
신은아, 박진규, Park No-Won, 김상봉, You Kyung-Jong, 이재준, 양우익,
소속 상세정보
신은아 ( Shin Eun-Ah )
Korea CFC Pathology Laboratory
박진규 ( Park Jin-Kyu )
Korea CFC Pathology Laboratory
( Park No-Won )
Korea CFC Pathology Laboratory
김상봉 ( Kim Sang-Bong )
Korea CFC Pathology Laboratory
( You Kyung-Jong )
Korea CFC Pathology Laboratory
이재준 ( Lee Jae-Joon )
Korea CFC Pathology Laboratory
양우익 ( Yang Woo-Ick )
Yonsei University College of Medicine Department of Pathology
KMID : 0357920110450060621
Abstract
Background : The Pap smear has brought about a dramatic improvement in the prevention of cervical cancer in women worldwide. In an effort to decrease the occasional false negatives in the Pap smear and further increase the screened population, ThinPrep Pap Test (TP), a fluid-based cytology collection method, has been developed. With preservation of claimed advantages of TP, we have developed a Pap test solution for manual preparatory process and compared our manually processed fluid-based Pap smear with TP to identify cytologic similarities and differences between the two methods.
Methods : Cervical swipes of 204 patients were prospectively collected in the ‘Pap solution’ and also in PreservCyt solution for TP. Diagnoses and smear characteristics were compared.
Results : The diagnoses of the paired smears agreed in 190 of the 204 cases (93.1%). The smear characteristics regarding overall cellularity and background cellularities were similar in the two methods and the stainability of the cells was virtually the same.
Conclusions : The ‘Pap solution’ has similar performance characteristics as TP in many aspects. With its advantages of cost-effectiveness and easier preparatory process, the ‘Pap solution’ can match previously implemented thin layer preparation.
키워드
Pap smear; ThinPrep; Manual preparation
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