Systemic Plasmacytosis - A Case Report with a Review of the Literature -
이성학, 유창영, 정지한, 유진영, 강석진, 강창석,
소속 상세정보
이성학 ( Lee Sung-Hak )
Catholic University College of Medicine Department of Hospital Pathology
유창영 ( Yoo Chang-Young )
Catholic University School of Medicine Department of Hospital Pathology
정지한 ( Jung Ji-Han )
Catholic University School of Medicine Department of Hospital Pathology
유진영 ( Yoo Jin-Young )
Catholic University College of Medicine Department of Hospital Pathology
강석진 ( Kang Suk-Jin )
Catholic University College of Medicine Department of Hospital Pathology
강창석 ( Kang Chang-Suk )
Catholic University College of Medicine Department of Hospital Pathology
KMID : 0357920110450060632
Abstract
Systemic plasmacytosis is an uncommon disorder characterized by widely disseminated macular skin eruptions composed of polyclonal lymphoplasmacytic infiltrates associated with variable extracutaneous involvement. An aggressive clinical course has been observed in a small number of patients, but most cases have followed chronic and benign clinical course without spontaneous remission. Previously reported cases of this entity have been described almost exclusively in Japanese patients. We recently experienced a case of systemic plasmacytosis in a 48-year-old Korean female patient. Initial skin biopsy specimen revealed patchy perivascular and periadnexal infiltrates of mature plasma cells. Serum immunoelectrophoresis revealed polyclonal hypergammaglobulinemia, and polyclonal plasmacytosis was noted on the subsequent biopsy specimens of left supraclavicular and axillary lymph nodes. Multiple tiny pulmonary nodules appeared six years after the initial cutaneous presentation and were found to be of the same histologic appearance. We herein report a rare case of systemic plasmacytosis with a review of the literature.
키워드
Plasmacytosis; Giant lymph node hyperplasia; Interleukin-6
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