The Ratio of Atypical Ductal Hyperplasia Foci to Core Numbers in Needle Biopsy: A Practical Index Predicting Breast Cancer in Subsequent Excision
이정주, 이희진, 강준, 조정현, 공경엽,
소속 상세정보
이정주 ( Lee Jeong-Ju )
University of Ulsan College of Medicine Department of Pathology
이희진 ( Lee Hee-Jin )
University of Ulsan College of Medicine Department of Pathology
강준 ( Kang Jun )
University of Ulsan College of Medicine Department of Pathology
조정현 ( Jo Jeong-Hyeon )
University of Ulsan College of Medicine Department of Pathology
공경엽 ( Gong Gyung-Yub )
University of Ulsan College of Medicine Department of Pathology
KMID : 0357920120460010015
Abstract
Background: Although core needle biopsy (CNB) is considered to be the standard technique for histological diagnosis of breast lesions, it is less reliable for diagnosing atypical ductal hyperplasia (ADH). We therefore assessed the characteristics of CNB-diagnosed ADH that are more likely to be associated with more advanced lesions on subsequent surgical excision.
Methods: We retrospectively examined 239 consecutive CNBs, 127 of which were diagnosed as ADH following surgical excision, performed at Asan Medical Center between 1995 and 2010. Archival slides were analyzed for the number of cores per specimen, the number of ADH foci, and the ratio of ADH foci to number of cores (FC ratio).
Results: We found that ADH foci in 3 or more cores (p=0.003) and the presence of ADH in 3 or more foci (p=0.002) were correlated with malignancy following excision lesion. Moreover, an FC>1.1 was significantly associated with malignancy in the subsequent excision (p=0.000).
Conclusions: Including the number of ADH foci, the number of cores involved according to ADH, FC ratio, and histologic type in a pathology report of CNB may help in making clinical decisions about surgical excision.
키워드
Atypical ductal hyperplasia; Core needle biopsy; Predictive pathologic factor
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